69 Best Machine Learning Startups in United States to Watch in 2025

The Definitive Seedtable Ranking of Machine Learning Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 136 start-ups with an aggregate funding of $15.9b. The average funding per company in this subset is $231.0m.

Last update to the database: Feb 18, 2025. See changelog.

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3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

1

Funding Rounds

$510.0k

Money raised

Wavel.ai is a voice AI solution for scaling and localizing video content.

10

Funding Rounds

$1.0b

Money raised

DataRobot sells a machine learning platform that helps users build and deploy accurate predictive models. The Boston-based company was founded in 2012 by Jeremy Achin.

6

Funding Rounds

$100.9m

Money raised

AppZen is a San Jose, California-based company that provides an AI-based auditing platform for finance teams.

Key people:

2

Funding Rounds

Hypergiant Industries is a machine learning and artificial intelligence company offering client-focused services and research and development in various fields. The company was founded by Ben Lamm and John Fremont in 2018.

2

Funding Rounds

$37.0m

Money raised

Blue Hexagon is a San Francisco-based cybersecurity company offering an on-device machine learning based malware detection product.

Key people:

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

6

Funding Rounds

$214.0m

Money raised

Observe.AI is the creator of an AI platform for call centers.

4

Funding Rounds

$3.2m

Money raised

MonkeyLearn is an artificial intelligence data analysis and visualization platform.

6

Funding Rounds

$9.8m

Money raised

Facial recognition company Kairos today announced the alpha release of the Kairos Protocol, a biometric verification system for cryptocurrency transactions.

8

Funding Rounds

$286.6m

Money raised

SparkCognition is an artificial intelligence and cybersecurity company offering cognitive computing analytics for the information technology, operational technology, and the internet of things (IoT) industries.

7

Funding Rounds

$30.3m

Money raised

Mattermark is a San Francisco-based company founded by Kevin Morrill, Danielle Morrill and Andy Sparks.

Key people:

4

Funding Rounds

$7.0m

Money raised

An artificial intelligence company developing a platform that helps analysts process and understand information.

1

Funding Rounds

$12.0m

Money raised

Amplemarket provides lead generation, email outreach, and lead qualification on autopilot.

Key people:

5

Funding Rounds

$150.3m

Money raised

Snorkel AI is a data-centric artificial intelligence company born out of Stanford University's AI Lab.

Key people:

10

Funding Rounds

$588.1m

Money raised

Shield AI is a company building artificially intelligent systems like drones for use by military service members and first responders.

9

Funding Rounds

$1.2b

Money raised

A company developing artificial intelligence-based technology designed for autonomous vehicles. It was founded in 2016 and is located in Fremont, California.

3

Funding Rounds

$2.9m

Money raised

Artificial Intelligence company using Augmented Reality for collaborative professional services

Key people:

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

6

Funding Rounds

$107.6m

Money raised

Zapata Computing is a company developing quantum software and algorithms for business founded in 2017 by Christopher Savoie, Alán Aspuru-Guzik, Jhonathan Romero Fontalvo, Jonathan Olson, Peter Johnson and Yudong Cao.

3

Funding Rounds

$47.0m

Money raised

Spatial has created a metaverse designed to give brands and creators a virtual space to display their digital works.

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

2

Funding Rounds

$15.5m

Money raised

Moesif is a Caifornia-based company providing API analytics and tools.

4

Funding Rounds

$20.1m

Money raised

Call analytics platform that uses artificial intelligence to transcribe and analyze sales calls, providing enterprises with actionable feedback to improve the performance of their sales teams.

15

Funding Rounds

$249.8m

Money raised

Sift Science is a San Francisco-based company founded in 2011 by Brandon Ballinger.

12

Funding Rounds

$296.1m

Money raised

BigID is a cybersecurity company developing a platform for data protection and privacy compliance.

Key people:

3

Funding Rounds

$34.7m

Money raised

Gideon is a robotics company that creates products for industrial settings.

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

7

Funding Rounds

$249.0m

Money raised

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

Key people:

5

Funding Rounds

$177.0m

Money raised

Capella Space is building a commercial radar satellite constellation. Its headquarters are located in San Francisco, California and it was founded in 2011.

Key people:

4

Funding Rounds

$45.0m

Money raised

Company providing service to identify and classify textual content with Artificial Intelligence

3

Funding Rounds

$52.0m

Money raised

3T Biosciences is a biotechnology company developing immunotherapies.

5

Funding Rounds

$62.7m

Money raised

QC Ware Corp. is a company that offers quantum computing software solutions for enterprises.

Key people:

5

Funding Rounds

$200.0m

Money raised

People.ai is an AI platform based on sales and marketing.

1

Funding Rounds

$3.0m

Money raised

Youper is an AI-based emotional health assistant company founded in 2016 by Jose Hamilton Vargas, Diego Dotta and Thiago Antonio Marafon.

5

Funding Rounds

$23.1m

Money raised

Iris Automation is a technology company specializing in artificial intelligence-based collision avoidance systems for industrial drones and other autonomous flying machines.

Key people:

7

Funding Rounds

$610.0m

Money raised

Newfront Insurance is a company that provides technologies that are designed to simplify brokerage processes

Key people:

3

Funding Rounds

$50.0m

Money raised

Anodot is a software development company that has created a business monitoring platform.

Key people:

3

Funding Rounds

$144.0m

Money raised

An insurance technology company offering a software platform for life insurance.

3

Funding Rounds

$475.0m

Money raised

Receivables and Treasury cloud software, powered by AI to optimize working capital.

Key people:

3

Funding Rounds

$62.0m

Money raised

A software company offering an open-source platform for machine learning and data science teams to create data applications with python.

5

Funding Rounds

$81.5m

Money raised

A blockchain platform for exchanging financial information without sharing data. It is located in Marina Del Rey, California and was founded in 2017.

Key people:

4

Funding Rounds

$1.7m

Money raised

Cyberwrite is a company which develops machine learning solutions and technologies for cyber insurance underwriting, pricing and aggregated risk management.

1

Funding Rounds

$27.0m

Money raised

Speak makes AI-based apps that help users learn languages by simulating real conversations.

4

Funding Rounds

$250.0k

Money raised

Local Motors is an American motor vehicle manufacturing company that is interested in providing low-volume vehicle manufacturing

7

Funding Rounds

$2.2b

Money raised

Nuro is a company that develops self-driving vehicles designed for local goods transportation.

8

Funding Rounds

$276.2m

Money raised

Feedzai is a San Mateo, California-based Information Technology & Services company.

Key people:

1

Funding Rounds

$6.0m

Money raised

A software media company that creates complex digital characters. It is located in Los Angeles, California and was founded in 2014.

5

Funding Rounds

$64.7m

Money raised

DefinedAI is an AI training data marketplace to buy, sell, or commission AI training data, tools, and models.

Key people:

6

Funding Rounds

$617.5m

Money raised

Bowery Farming is a New York-based agriculture company focused on building indoor vertical farms.

Key people:

1

Funding Rounds

$40.0m

Money raised

NewLimit is a biotechnology company focusing on developing epigenetic reprogramming therapies that aid with illnesses that are normally associated with aging.

5

Funding Rounds

$327.4m

Money raised

An application that allows its users to pay bills online using their own credit cards. It is located in Sydney, Australia and was founded in 2017.

Location:

Key people:

4

Funding Rounds

$355.0m

Money raised

WorkFusion is a New York-based software company that provides a platform with Robotic Process Automation(RPA) and Artificial Intelligence (AI).

2

Funding Rounds

$23.3m

Money raised

A technology company developing technologies for self driving vehicles.

2

Funding Rounds

$11.5m

Money raised

Murf.AI hosts an artifical intelligence-based text-to-speech platform for use in the creation of humanlike voiceovers.

Key people:

2

Funding Rounds

$13.8m

Money raised

Citadel builds an automated and modular drone defense system that uses machine learning algorithms to detect and engage drones.

5

Funding Rounds

$8.7m

Money raised

An artificial intelligence company using computer vision to monitor, identify patterns, and make decisions based on surveillance camera streams.

4

Funding Rounds

$1.2m

Money raised

Eino is a US company making artificial intelligence for mobile capacity planning.

Key people:

8

Funding Rounds

$28.7m

Money raised

Bold Metrics is a San Francisco-based company founded by Morgan Linton.

Key people:

5

Funding Rounds

$8.3m

Money raised

Skyward developed an operations management solution for commercial drone businesses. Acquired by Verizon.

Location:

Key people:

2

Funding Rounds

$12.5m

Money raised

A software quality assurance automation platform powered by artificial intelligence.

1

Funding Rounds

$30.0m

Money raised

Modular offers a platform for AI developers that aims to enable the development and deployment of machine learning solutions.

Key people:

1

Funding Rounds

A medical technology company building online open intelligence system for improving patient health.

2

Funding Rounds

$53.0m

Money raised

Engine Biosciences is a San Francisco-based AI company that is focused on drugs development.

Key people:

2

Funding Rounds

$3.6b

Money raised

Argo AI is a Pittsburgh-based artificial intelligence and self-driving technology platform company.

1

Funding Rounds

$3.5m

Money raised

TraceAir creates and develops software solutions using drone imaging to assist construction teams with creating a better picture of their projects.

Key people:

3

Funding Rounds

$99.3m

Money raised

BigHat Biosciences is a company with a mission to enhance human health by making it easier to design advanced antibody therapeutics.

Key people:

6

Funding Rounds

$15.6m

Money raised

Elistair is a company that develops equipment for the aviation industry.

Key people:

3

Funding Rounds

$84.0m

Money raised

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