69 Best Machine Learning Startups in United States to Watch in 2026

The Definitive Seedtable Ranking of Machine Learning Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 138 start-ups with an aggregate funding of $16.5b. The average funding per company in this subset is $239.4m.

Last update to the database: May 19, 2026. See changelog.

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7

Funding Rounds

$280.9m

Money raised

AppZen is a San Jose, California-based company that provides an AI-based auditing platform for finance teams.

Key people:

7

Funding Rounds

$350.3m

Money raised

Snorkel AI is a data-centric artificial intelligence company born out of Stanford University's AI Lab.

8

Funding Rounds

$2.4b

Money raised

Nuro is a company that develops self-driving vehicles designed for local goods transportation.

2

Funding Rounds

$280.0m

Money raised

Modular offers a platform for AI developers that aims to enable the development and deployment of machine learning solutions.

Key people:

10

Funding Rounds

$1.0b

Money raised

DataRobot sells a machine learning platform that helps users build and deploy accurate predictive models. The Boston-based company was founded in 2012 by Jeremy Achin.

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

5

Funding Rounds

$177.0m

Money raised

Capella Space is building a commercial radar satellite constellation. Its headquarters are located in San Francisco, California and it was founded in 2011.

Key people:

7

Funding Rounds

$610.0m

Money raised

Newfront Insurance is a company that provides technologies that are designed to simplify brokerage processes

Key people:

3

Funding Rounds

$144.0m

Money raised

An insurance technology company offering a software platform for life insurance.

5

Funding Rounds

$64.7m

Money raised

DefinedAI is an AI training data marketplace to buy, sell, or commission AI training data, tools, and models.

Key people:

6

Funding Rounds

$617.5m

Money raised

Bowery Farming is a New York-based agriculture company focused on building indoor vertical farms.

Key people:

5

Funding Rounds

$400.0m

Money raised

WorkFusion is a New York-based software company that provides a platform with Robotic Process Automation(RPA) and Artificial Intelligence (AI).

2

Funding Rounds

$3.6b

Money raised

Argo AI is a Pittsburgh-based artificial intelligence and self-driving technology platform company.

3

Funding Rounds

$99.3m

Money raised

BigHat Biosciences is a company with a mission to enhance human health by making it easier to design advanced antibody therapeutics.

Key people:

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

6

Funding Rounds

$214.0m

Money raised

Observe.AI is the creator of an AI platform for call centers.

8

Funding Rounds

$286.6m

Money raised

SparkCognition is an artificial intelligence and cybersecurity company offering cognitive computing analytics for the information technology, operational technology, and the internet of things (IoT) industries.

4

Funding Rounds

$58.0m

Money raised

3T Biosciences is a biotechnology company developing immunotherapies.

Key people:

3

Funding Rounds

$50.0m

Money raised

Anodot is a software development company that has created a business monitoring platform.

Key people:

3

Funding Rounds

$62.0m

Money raised

A software company offering an open-source platform for machine learning and data science teams to create data applications with python.

2

Funding Rounds

$53.0m

Money raised

Engine Biosciences is a San Francisco-based AI company that is focused on drugs development.

Key people:

3

Funding Rounds

$84.0m

Money raised

Ordr Systems Control Engine. The first actionable AI-based systems control engine for the hyper-connected enterprise. You're in control.

10

Funding Rounds

$588.1m

Money raised

Shield AI is a company building artificially intelligent systems like drones for use by military service members and first responders.

3

Funding Rounds

$34.7m

Money raised

Gideon is a robotics company that creates products for industrial settings.

4

Funding Rounds

$45.0m

Money raised

Company providing service to identify and classify textual content with Artificial Intelligence

1

Funding Rounds

$27.0m

Money raised

Speak makes AI-based apps that help users learn languages by simulating real conversations.

7

Funding Rounds

$30.3m

Money raised

Mattermark is a San Francisco-based company founded by Kevin Morrill, Danielle Morrill and Andy Sparks.

Key people:

7

Funding Rounds

$249.0m

Money raised

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

Key people:

5

Funding Rounds

$200.0m

Money raised

People.ai is an AI platform based on sales and marketing.

8

Funding Rounds

$28.7m

Money raised

Bold Metrics is a San Francisco-based company founded by Morgan Linton.

Key people:

3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

9

Funding Rounds

$1.2b

Money raised

A company developing artificial intelligence-based technology designed for autonomous vehicles. It was founded in 2016 and is located in Fremont, California.

6

Funding Rounds

$107.6m

Money raised

Zapata Computing is a company developing quantum software and algorithms for business founded in 2017 by Christopher Savoie, Alán Aspuru-Guzik, Jhonathan Romero Fontalvo, Jonathan Olson, Peter Johnson and Yudong Cao.

Key people:

15

Funding Rounds

$249.8m

Money raised

Sift Science is a San Francisco-based company founded in 2011 by Brandon Ballinger.

12

Funding Rounds

$296.1m

Money raised

BigID is a cybersecurity company developing a platform for data protection and privacy compliance.

Key people:

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

5

Funding Rounds

$62.7m

Money raised

QC Ware Corp. is a company that offers quantum computing software solutions for enterprises.

Key people:

3

Funding Rounds

$475.0m

Money raised

Receivables and Treasury cloud software, powered by AI to optimize working capital.

Key people:

5

Funding Rounds

$81.5m

Money raised

A blockchain platform for exchanging financial information without sharing data. It is located in Marina Del Rey, California and was founded in 2017.

Key people:

1

Funding Rounds

$6.0m

Money raised

A software media company that creates complex digital characters. It is located in Los Angeles, California and was founded in 2014.

5

Funding Rounds

$327.4m

Money raised

An application that allows its users to pay bills online using their own credit cards. It is located in Sydney, Australia and was founded in 2017.

Location:

Key people:

2

Funding Rounds

$11.5m

Money raised

Murf.AI hosts an artifical intelligence-based text-to-speech platform for use in the creation of humanlike voiceovers.

Key people:

2

Funding Rounds

$12.1m

Money raised

Lunar Outpost is a Colorado based aerospace technology company, currently focused on developing space resource technologies.

2

Funding Rounds

$37.0m

Money raised

Blue Hexagon is a San Francisco-based cybersecurity company offering an on-device machine learning based malware detection product.

Key people:

3

Funding Rounds

$47.0m

Money raised

Spatial has created a metaverse designed to give brands and creators a virtual space to display their digital works.

4

Funding Rounds

$20.1m

Money raised

Call analytics platform that uses artificial intelligence to transcribe and analyze sales calls, providing enterprises with actionable feedback to improve the performance of their sales teams.

5

Funding Rounds

$23.1m

Money raised

Iris Automation is a technology company specializing in artificial intelligence-based collision avoidance systems for industrial drones and other autonomous flying machines.

Key people:

2

Funding Rounds

$23.3m

Money raised

A technology company developing technologies for self driving vehicles.

5

Funding Rounds

$8.7m

Money raised

An artificial intelligence company using computer vision to monitor, identify patterns, and make decisions based on surveillance camera streams.

4

Funding Rounds

$3.2m

Money raised

MonkeyLearn is an artificial intelligence data analysis and visualization platform.

6

Funding Rounds

$9.8m

Money raised

Facial recognition company Kairos today announced the alpha release of the Kairos Protocol, a biometric verification system for cryptocurrency transactions.

4

Funding Rounds

$7.0m

Money raised

An artificial intelligence company developing a platform that helps analysts process and understand information.

1

Funding Rounds

$12.0m

Money raised

Amplemarket provides lead generation, email outreach, and lead qualification on autopilot.

Key people:

2

Funding Rounds

$15.5m

Money raised

Moesif is a Caifornia-based company providing API analytics and tools.

2

Funding Rounds

$13.8m

Money raised

Citadel builds an automated and modular drone defense system that uses machine learning algorithms to detect and engage drones.

5

Funding Rounds

$8.3m

Money raised

Skyward developed an operations management solution for commercial drone businesses. Acquired by Verizon.

Location:

Key people:

2

Funding Rounds

$12.5m

Money raised

A software quality assurance automation platform powered by artificial intelligence.

6

Funding Rounds

$15.6m

Money raised

Elistair is a company that develops equipment for the aviation industry.

Key people:

3

Funding Rounds

$2.9m

Money raised

Artificial Intelligence company using Augmented Reality for collaborative professional services

Key people:

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

1

Funding Rounds

$3.0m

Money raised

Youper is an AI-based emotional health assistant company founded in 2016 by Jose Hamilton Vargas, Diego Dotta and Thiago Antonio Marafon.

1

Funding Rounds

Spear AI specializes in the provision of a defense AI platform for government partners.

1

Funding Rounds

$3.5m

Money raised

TraceAir creates and develops software solutions using drone imaging to assist construction teams with creating a better picture of their projects.

Key people:

1

Funding Rounds

$510.0k

Money raised

Wavel.ai is a voice AI solution for scaling and localizing video content.

2

Funding Rounds

Hypergiant Industries is a machine learning and artificial intelligence company offering client-focused services and research and development in various fields. The company was founded by Ben Lamm and John Fremont in 2018.

4

Funding Rounds

$1.7m

Money raised

Cyberwrite is a company which develops machine learning solutions and technologies for cyber insurance underwriting, pricing and aggregated risk management.

4

Funding Rounds

$250.0k

Money raised

Local Motors is an American motor vehicle manufacturing company that is interested in providing low-volume vehicle manufacturing

4

Funding Rounds

$1.2m

Money raised

Eino is a US company making artificial intelligence for mobile capacity planning.

Key people:

1

Funding Rounds

A medical technology company building online open intelligence system for improving patient health.

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