69 Best Machine Learning Startups in San Francisco to Watch in 2026

The Definitive Seedtable Ranking of Machine Learning Startups in San Francisco

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 348 start-ups with an aggregate funding of $318.4b. The average funding per company in this subset is $4.6b.

Last update to the database: May 12, 2026. See changelog.

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11

Funding Rounds

$298.5b

Money raised

OpenAI is an AI research and deployment platform.

Location:

Key people:

9

Funding Rounds

$857.3m

Money raised

Replit is a San Francisco-based IDE and software development environment company making a browser application platform for coding in over fifty programming languages.

Location:

Key people:

11

Funding Rounds

$5.0b

Money raised

AI safety and research platform.

Location:

Key people:

11

Funding Rounds

$1.3b

Money raised

Zipline is an automated logistics company that designs, manufactures, and delivers medical products.

Industries:

Key people:

4

Funding Rounds

$51.6m

Money raised

Wispr is a personal computing platform for an AI-first world.

4

Funding Rounds

$967.3m

Money raised

Luma AI is a developer of photorealistic 3D image capture software designed to enable users to capture 3D-viewable photos of scenes and objects on smartphones.

4

Funding Rounds

$145.0m

Money raised

You.com is an ad-free, private search engine.

Location:

Key people:

4

Funding Rounds

$74.3m

Money raised

Pachama is a company estimating carbon storage in forests and predicting future deforestation or potential for forest restoration with the use of satellite images.

6

Funding Rounds

$602.6m

Money raised

Scale AI is an artificial intelligence company making an API for validating and training data for applications.

4

Funding Rounds

$92.0m

Money raised

Forethought is a San Francisco-based company providing customer service automation using generative AI technology.

Key people:

6

Funding Rounds

$215.0m

Money raised

Tecton is a machine learning DevOps platform for data scientists.

Location:

Key people:

2

Funding Rounds

$415.0m

Money raised

Adept AI Labs is a machine learning research and product lab building general intelligence systems

Location:

Key people:

3

Funding Rounds

$113.0m

Money raised

Zilliz is a vector database company providing products for enterprise-grade AI.

4

Funding Rounds

$160.0m

Money raised

Suki is a Redwood City, California-based technology company developing AI-powered administrative tools for the healthcare industry.

6

Funding Rounds

$490.0m

Money raised

Grammarly is an AI-powered writing assistant tool provider founded in 2009 by Alex Shevchenko, Max Lytvyn and Dmytro Lider.

Location:

Key people:

5

Funding Rounds

$162.5m

Money raised

A company offering a communications platform allows developers to quickly build features that connect to every email, calendar, and contacts provider in the world.

8

Funding Rounds

$427.9m

Money raised

Standard AI is a software company creating autonomous checkout systems for retailers.

5

Funding Rounds

$249.5m

Money raised

Viz.ai is a healthcare startup that uses artificial intelligence to identify early signs of stroke.

5

Funding Rounds

$177.0m

Money raised

Capella Space is building a commercial radar satellite constellation. Its headquarters are located in San Francisco, California and it was founded in 2011.

Key people:

4

Funding Rounds

$92.0m

Money raised

Faeth Therapeutics is a start-up that focuses on using nutrition and metabolism to fight cancer.

Location:

Key people:

6

Funding Rounds

$214.0m

Money raised

Observe.AI is the creator of an AI platform for call centers.

4

Funding Rounds

$159.0m

Money raised

Aera Technology is a software company offering business automation functions.

5

Funding Rounds

$108.1m

Money raised

AssemblyAI is a speech AI company developing AI models capable of transcribing and understanding human speech.

6

Funding Rounds

$80.4m

Money raised

Rasa is a company that offers a conversational AI platform for customized conversations at scale.

4

Funding Rounds

$55.5m

Money raised

Ceres Imaging is a California-based aerial spectral imagery and analytics company that serves farmers and agribusinesses.

Key people:

4

Funding Rounds

$58.0m

Money raised

3T Biosciences is a biotechnology company developing immunotherapies.

Key people:

7

Funding Rounds

$128.9m

Money raised

Dredrone is an airspace security platform that detects, classifies, and mitigates drone threats.

4

Funding Rounds

$204.7m

Money raised

Primer is a San Francisco-based company developing AI to generate written intelligence reports.

3

Funding Rounds

$47.0m

Money raised

Paravision is a San Francisco-based provider of facial recognition and activity monitoring software. Paravision was previously known as Ever AI.

Location:

Key people:

6

Funding Rounds

$30.0m

Money raised

Rain AI is a company developing a new AI compute platform by co-designing every layer of the AI stack.

4

Funding Rounds

$20.0m

Money raised

A company offering an audio word processing platform that enables editor and producers to edit sound files while a writer would edit its lyrics.

Location:

Key people:

5

Funding Rounds

$120.7m

Money raised

Hive is an artificial intelligence software company specializing in deep learning and computer vision.

Location:

Key people:

4

Funding Rounds

$45.0m

Money raised

Company providing service to identify and classify textual content with Artificial Intelligence

4

Funding Rounds

$43.9m

Money raised

Iterative.ai is a machine learning and artificial intelligence training platform provider.

3

Funding Rounds

$21.0m

Money raised

Kite.Com is a San Francisco-based company that builds AI-powered auto-complete features for developers.

7

Funding Rounds

$30.3m

Money raised

Mattermark is a San Francisco-based company founded by Kevin Morrill, Danielle Morrill and Andy Sparks.

Key people:

2

Funding Rounds

$28.7m

Money raised

Predibase is a company developing a low-code AI platform for developers.

Location:

Key people:

7

Funding Rounds

$249.0m

Money raised

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

Key people:

5

Funding Rounds

$200.0m

Money raised

People.ai is an AI platform based on sales and marketing.

4

Funding Rounds

$964.2m

Money raised

Neuralink is a company that develops brain-computer interface (BCI) devices to assist people with paralysis and blindness and technologies that may expand the abilities of humans.

3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

8

Funding Rounds

$3.0b

Money raised

Postmates is a food delivery service company operating a network of couriers for local goods delivery.

6

Funding Rounds

$53.9m

Money raised

Sight Machine's manufacturing software platform uses an artificial intelligence (AI) platform to help improve quality and efficiency across a manufacturing enterprise.

4

Funding Rounds

$188.9m

Money raised

Labelbox is a training data platform with labeling tools, human workforce, data management, API, and automation features for computer vision.

7

Funding Rounds

$220.5m

Money raised

Domino Data Lab is a machine learning platform enabling data science teams to rapidly develop and deploy models that drive breakthrough innovation

Location:

Key people:

2

Funding Rounds

$8.5m

Money raised

LlamaIndex is an open-source data framework for connecting custom datasets with large language models (LLMs) in order to build applications.

Location:

Key people:

4

Funding Rounds

$75.1m

Money raised

Volansi was a company offering delivery service for time-critical shipments using high-speed long-range drones. Volansi was acquired by Sierra Nevada Corporation in October 2022.

2

Funding Rounds

$10.6m

Money raised

MindsDB is a Berkeley, California-based developer of machine learning capabilities capable of being integrated into databases.

7

Funding Rounds

$64.3m

Money raised

Casetext is an AI legal research technology company. It was acquired by Thomson Reuters Corporation in June 2023.

4

Funding Rounds

$105.7m

Money raised

SafeGraph is a data company offering a platform for organizing points of interests (POIs) relevant to businesses. It was founded in 2016 and is located in San Francisco, California.

15

Funding Rounds

$249.8m

Money raised

Sift Science is a San Francisco-based company founded in 2011 by Brandon Ballinger.

12

Funding Rounds

$296.1m

Money raised

BigID is a cybersecurity company developing a platform for data protection and privacy compliance.

Key people:

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

6

Funding Rounds

$96.3m

Money raised

An artificial intelligence company developing deep reinforcement learning technology products for industrial automation.

Industries:

Location:

Key people:

4

Funding Rounds

$50.2m

Money raised

Replicate is a company developing a platform for running machine learning models in the cloud.

11

Funding Rounds

$142.5m

Money raised

DroneDeploy is a cloud-based software that allows drones to take images and 3D models at any altitude.

Key people:

4

Funding Rounds

$20.1m

Money raised

Call analytics platform that uses artificial intelligence to transcribe and analyze sales calls, providing enterprises with actionable feedback to improve the performance of their sales teams.

2

Funding Rounds

$20.3m

Money raised

Chroma is a company developing an open-source embedding database (or vector database) for developing LLM apps.

1

Funding Rounds

$36.0m

Money raised

TurbineOne is the frontline perception company.

Location:

Key people:

11

Funding Rounds

$29.6m

Money raised

A company that provides a data platform for buildings and properties.

Location:

Key people:

4

Funding Rounds

$3.2m

Money raised

MonkeyLearn is an artificial intelligence data analysis and visualization platform.

1

Funding Rounds

$12.0m

Money raised

Amplemarket provides lead generation, email outreach, and lead qualification on autopilot.

Key people:

1

Funding Rounds

$9.4m

Money raised

Datatron is an artificial Intelligence company providing machine learning, artificial intelligence, and data science models for user models.

2

Funding Rounds

$15.5m

Money raised

Moesif is a Caifornia-based company providing API analytics and tools.

2

Funding Rounds

$13.6m

Money raised

Determined AI offers an open-source deep learning platform for building algorithmic models.

4

Funding Rounds

$18.5m

Money raised

Agent IQ is a company that offers a personal digital platform powered by AI to enhance communication and engagement between banks, credit unions, and their customers.

Key people:

3

Funding Rounds

$2.9m

Money raised

Artificial Intelligence company using Augmented Reality for collaborative professional services

Key people:

1

Funding Rounds

$2.0m

Money raised

Cardiogram is a company building a personal healthcare assistant, using Deep Learning to turn consumer wearables into continuous health monitors. Cariogram can now detect 4 medical conditions Sleep Apnea, High Blood Pressure, Atrial Fibrillation, and Diabetes.

Location:

Key people:

1

Funding Rounds

$1.6m

Money raised

Flike is building machine learning (ML)-powered recommender APIs to help engineers personalize discovery pages, feeds, recommended content, customer communication, and more.

Location:

Key people:

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