69 Best Engineering Startups in United States to Watch in 2025

The Definitive Seedtable Ranking of Engineering Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 406 start-ups with an aggregate funding of $11.2b. The average funding per company in this subset is $162.5m.

Last update to the database: Feb 18, 2025. See changelog.

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5

Funding Rounds

$72.2m

Money raised

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Key people:

10

Funding Rounds

$930.0m

Money raised

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

4

Funding Rounds

$1.8b

Money raised

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

3

Funding Rounds

$125.0m

Money raised

Synchron, Inc. is a technology company building implantable neural interface solutions, including endovascular brain-computer interface.

8

Funding Rounds

$71.3m

Money raised

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

9

Funding Rounds

$276.0m

Money raised

A diagnostic DNA testing company using quantified biological data.

3

Funding Rounds

$14.3m

Money raised

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

2

Funding Rounds

$158.0m

Money raised

Senti Biosciences is a synthetic biology company.

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

5

Funding Rounds

$104.5m

Money raised

A cellular agriculture company making fresh and frozen cultured seafood products.

Key people:

13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

3

Funding Rounds

$21.5m

Money raised

RoosterBio is a biotechnology company located in Frederick, Maryland, founded by Jon Rowley in 2013 providing standardized stem cell products for R&D, clinical, and commercial use in the regenerative medicine industry.

5

Funding Rounds

$111.8m

Money raised

Orig3n is a biotechnology company developing personalized regenerative medicine treatments based on patient genetic profiles.

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

Key people:

8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Key people:

16

Funding Rounds

$328.8m

Money raised

ViaCyte is a biotechnology company using stem cells to create pancreatic beta cell precursors for treating diabetes.

6

Funding Rounds

$15.8m

Money raised

Massive Bio is a New York-based company founded by Selin Kurnaz, Dr. Arturo Loaiza-Bonilla and Cagatay M. Culcuoglu, offering precision oncology services to cancer patients, providers, and pharmaceutical companies.

2

Funding Rounds

$13.8m

Money raised

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

2

Funding Rounds

$192.0m

Money raised

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

1

Funding Rounds

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

2

Funding Rounds

$98.0m

Money raised

OrphAI Therapeutics is a biotechnology research company based in Guilford, Connecticut that develops precision therapeutics technology designed to treat cancer and rare diseases.

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

3

Funding Rounds

$8.6m

Money raised

Nebula Genomics is a genetics company developing a platform for individuals to get their personal genome sequenced, and then enable them to store and control that information through cryptographic encryption on the blockchain.

Key people:

2

Funding Rounds

$164.5m

Money raised

Develops novel cell and gene therapies with pharmacologic operating systems.

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

4

Funding Rounds

$119.5m

Money raised

Wild Type is a San Francisco based company producing meat products like salmon using cellular agriculture lab techniques.

Key people:

8

Funding Rounds

$967.6m

Money raised

Freenome is a San Francisco-based company which uses genetic analysis for early cancer detection and risk assessment.

2

Funding Rounds

$18.1m

Money raised

A biotechnology company that develops treatments for cancer and hematologic conditions

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

5

Funding Rounds

$2.5m

Money raised

Ichor Therapeutics is a pre-clinical contract research on aging mechanisms company founded in 2013 by Kelsey Moody.

Key people:

5

Funding Rounds

$26.8m

Money raised

A biotechnology company developing live attenuated vaccines. It was founded in 2012 and is located in New York.

7

Funding Rounds

$249.0m

Money raised

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

Key people:

3

Funding Rounds

$52.0m

Money raised

3T Biosciences is a biotechnology company developing immunotherapies.

4

Funding Rounds

$30.0m

Money raised

Company manufacturing 3d printed pharmaceuticals based in San Francisco, CA

Key people:

4

Funding Rounds

$20.5m

Money raised

Zeteo Tech is a company founded by Charles Call.

4

Funding Rounds

$87.8m

Money raised

DNA synthesis company using enzymatic DNA synthesis based in San Francisco.

7

Funding Rounds

$102.9m

Money raised

Xenex Disinfection Services is a company that provides pulsed xenon ultraviolet-C, room disinfection systems to healthcare facilities

Key people:

1

Funding Rounds

$10.5m

Money raised

SmartPharm Therapeutics is a Cambridge, MA-based gene therapy company applying the next generation of non-viral DNA and RNA technologies to treat serious human diseases.

5

Funding Rounds

$425.0m

Money raised

Tmunity Therapeutics is a biotechnology company developing t-cell immunotherapies for the treatment of human diseases.

5

Funding Rounds

$14.5m

Money raised

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

Key people:

1

Funding Rounds

$2.0m

Money raised

Allevi, formerly known as BioBots, is a technology company making 3 dimensional bioprinters and bioinks for their printers. The company was founded in 2014 and located in Philadelphia, Pennsylvania.

Industries:

Key people:

1

Funding Rounds

$1.0m

Money raised

Sanguine is a company that has the mission to accelerate medical research by eliminating the barriers to patient participation.

3

Funding Rounds

$59.5m

Money raised

64x Bio is a biotechnology company developing a platform for improving speed and scalability of mammalian cell line discovery for pharmaceutical and biotechnology companies.

3

Funding Rounds

$41.6m

Money raised

A biotechnology and industrial automation company. It was founded in 2010 and is located in San Francisco, California.

Key people:

4

Funding Rounds

$185.0k

Money raised

Forcyte Biotechnologies is a Los Angeles-based biotechnology company, founded in 2017.

2

Funding Rounds

$40.0m

Money raised

54Gene is healthcare startup company providing a genetics testing platform in Africa. It also offers genetic reports on health, nutrition, fitness and weight loss, carrier status, personal traits and ancestry.

Key people:

2

Funding Rounds

$16.6m

Money raised

Protein tests company based in Berkeley founded by Akwasi Apori

1

Funding Rounds

$4.0m

Money raised

A pharmaceutical company that uses a zebrafish drug-screening platform to find drug candidate molecules that have the capacity to promote regeneration of tissues. Their drug candidate MSI-1436 is being developed and tested for the treatment of heart disease, Duchenne Muscular Dystrophy and diabetic nephropathy.

5

Funding Rounds

$134.1m

Money raised

Verge Genomics is a company focused on the discovery and development of drugs for the treatment of neurodegenerative diseases with the use of machine learning and computational genomics.

Key people:

1

Funding Rounds

$1.5m

Money raised

CSPA (Computer Science Proficiency Assessment) is a company providing standardized assessment for software engineers. It is located in San Francisco, California and was founded in 2017.The Computer Science Proficiency Assessment (CSPA™) is a comprehensive standardized exam for software engineers.

1

Funding Rounds

$3.9m

Money raised

Tempo Therapeutics is an interventional biomaterials for regenerative medicine company founded by Westbrook Weaver.

Key people:

1

Funding Rounds

$1.7m

Money raised

Celdara Medical is a biotechnology company helping turn academic innovations into medical products.

Key people:

4

Funding Rounds

$107.2m

Money raised

Culture Biology is a synthetic biology company offering a bioreactor facility for fermentation on demand services.

Key people:

4

Funding Rounds

$40.4m

Money raised

Biotechnology software company offering protein modelling and design capabilities.

Key people:

2

Funding Rounds

$4.7m

Money raised

Biotechnology company providing protein analysis tools and commercializing diagnostic tests

2

Funding Rounds

$105.0m

Money raised

Eureka Therapeutics is a biotechnology company developing immunotherapies for the treatment of cancer.

1

Funding Rounds

$2.5m

Money raised

BiomeSense, Inc. is a biotechnology company developing microbiome technologies for the collection, storage, and analysis of gut microbiome profiles.

Key people:

8

Funding Rounds

$25.4m

Money raised

Biosortia is a therapeutics, agrochemical and cosmetics company developing products from microbial small molecules through microbiome mining.

2

Funding Rounds

$91.5m

Money raised

Design, integrate, and automate document workflows using a single platform.

2

Funding Rounds

$60.6m

Money raised

A biotechnology company developing nucleic acid immunotherapy platform and protein based vaccines

4

Funding Rounds

$364.1m

Money raised

Dewpoint Therapeutics is a US-based drug manufacturing company.

4

Funding Rounds

$270.0m

Money raised

Small Molecules

Location:

Key people:

6

Funding Rounds

$117.7m

Money raised

AliveCor is a San Francisco-based company developing AI-based ECG technologies.

3

Funding Rounds

$50.6m

Money raised

Cambridge, MA-based company developing targeted mRNA therapeutics for cancer and other diseases.

Key people:

2

Funding Rounds

$59.3m

Money raised

Renovia is a Boston-based medical device company developing diagnostic and therapeutic devices for women with pelvic floor disorders.

2

Funding Rounds

$207.5m

Money raised

Korro Bio is a biotechnology company based in Cambridge, Massachusetts focused on the research and development of RNA editing technology.

11

Funding Rounds

$35.7m

Money raised

Lightpoint Medical is a solutions developer and provider for the health care industry, specializing in the development of intra-operative, robot-guided systems.

Key people:

2

Funding Rounds

$33.9m

Money raised

Refuge Biotechnologies is a biotechnology company that uses CRISPR and cell therapy technologies for treating cancer.

Key people:

10

Funding Rounds

$786.3m

Money raised

A quantum physics and AI drug research and development company

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