69 Best Biotechnology Startups in United States to Watch in 2025

The Definitive Seedtable Ranking of Biotechnology Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 574 start-ups with an aggregate funding of $16.0b. The average funding per company in this subset is $232.5m.

Last update to the database: Feb 18, 2025. See changelog.

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5

Funding Rounds

$72.2m

Money raised

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Key people:

8

Funding Rounds

$406.4m

Money raised

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

7

Funding Rounds

$711.5m

Money raised

Perfect Day Foods (formerly Muufri) engineered yeast capable of producing the proteins found in cows milk. They use these proteins to make their own line of animal-free dairy products.

Key people:

10

Funding Rounds

$930.0m

Money raised

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

8

Funding Rounds

$551.0m

Money raised

Eat Just is a San Francisco based food technology company founded in 2011. The company is known for its bean-based egg substitute called Just Egg. Eat Just also produces egg-free mayonnaise.

4

Funding Rounds

$1.8b

Money raised

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

21

Funding Rounds

$1.9b

Money raised

Apeel Sciences is a company that develops treatments to prevent spoilage of fruits and vegetables using molecules naturally found in peels, which maintain moisture and keep out oxygen.

3

Funding Rounds

$125.0m

Money raised

Synchron, Inc. is a technology company building implantable neural interface solutions, including endovascular brain-computer interface.

8

Funding Rounds

$71.3m

Money raised

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

9

Funding Rounds

$276.0m

Money raised

A diagnostic DNA testing company using quantified biological data.

2

Funding Rounds

$14.6m

Money raised

A biotechnology company that has built a robotic cloud lab which allows on-demand services for biology laboratories.

Key people:

3

Funding Rounds

$14.3m

Money raised

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

5

Funding Rounds

$457.2m

Money raised

EGenesis is a gene editing and genome engineering company developing human-compatible engineered organs to treat diseases

Key people:

2

Funding Rounds

$158.0m

Money raised

Senti Biosciences is a synthetic biology company.

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

5

Funding Rounds

$104.5m

Money raised

A cellular agriculture company making fresh and frozen cultured seafood products.

Key people:

3

Funding Rounds

$313.0m

Money raised

Flatiron Health is a startup that organizes real-time oncology data to help cancer patients and doctors.

13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

3

Funding Rounds

$21.5m

Money raised

RoosterBio is a biotechnology company located in Frederick, Maryland, founded by Jon Rowley in 2013 providing standardized stem cell products for R&D, clinical, and commercial use in the regenerative medicine industry.

5

Funding Rounds

$111.8m

Money raised

Orig3n is a biotechnology company developing personalized regenerative medicine treatments based on patient genetic profiles.

1

Funding Rounds

$24.1m

Money raised

Neos Therapeutics is a pharmaceutical company developing ADHD medications founded in 2008.

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

Key people:

8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Key people:

16

Funding Rounds

$328.8m

Money raised

ViaCyte is a biotechnology company using stem cells to create pancreatic beta cell precursors for treating diabetes.

7

Funding Rounds

$21.2m

Money raised

Wild Earth is a biotechnology company using cellular agriculture to produce high-protein pet food.

1

Funding Rounds

$32.0m

Money raised

Air Protein is a Berkeley-based biotechnology company producing protein with microorganisms that are fed carbon dioxide in a mission to replace animal agriculture.

6

Funding Rounds

$15.8m

Money raised

Massive Bio is a New York-based company founded by Selin Kurnaz, Dr. Arturo Loaiza-Bonilla and Cagatay M. Culcuoglu, offering precision oncology services to cancer patients, providers, and pharmaceutical companies.

2

Funding Rounds

$13.8m

Money raised

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

3

Funding Rounds

$32.0m

Money raised

miRagen is a clinical stage biopharmaceutical company developing innovative microRNA-targeting therapies to improve human health.

Key people:

8

Funding Rounds

$1.1b

Money raised

Pivot Bio is a company that creates technology that is focused on nitrogen fixation in cereal crops through microbes.It was founded in 2010 and is located in Berkeley, California.

2

Funding Rounds

$192.0m

Money raised

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

1

Funding Rounds

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

2

Funding Rounds

$98.0m

Money raised

OrphAI Therapeutics is a biotechnology research company based in Guilford, Connecticut that develops precision therapeutics technology designed to treat cancer and rare diseases.

3

Funding Rounds

$54.1k

Money raised

ApexQubit is a biotechnology company that is harnessing a proprietary technology for discovery of new medicines to treat patients with undruggable diseases.

2

Funding Rounds

$22.8m

Money raised

Emerald Therapeutics is a biotechnology company located in San Fransisco, California, founded by Brian Frezza and DJ Klienbaum in 2010. Emerald Therapeutics offers cloud a based software and hardware platform that allows researchers to remotely perform automated scientific laboratory experiments.

10

Funding Rounds

$36.3m

Money raised

Chronicled is a blockchain company founded by Ryan Orr, Samantha Radocchia, Maurizio Greco and David Aho.

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

3

Funding Rounds

$8.6m

Money raised

Nebula Genomics is a genetics company developing a platform for individuals to get their personal genome sequenced, and then enable them to store and control that information through cryptographic encryption on the blockchain.

Key people:

2

Funding Rounds

$164.5m

Money raised

Develops novel cell and gene therapies with pharmacologic operating systems.

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

8

Funding Rounds

$166.0m

Money raised

Axiom Space is a company that is primarily interested in providing human spaceflight services

Key people:

4

Funding Rounds

$119.5m

Money raised

Wild Type is a San Francisco based company producing meat products like salmon using cellular agriculture lab techniques.

Key people:

8

Funding Rounds

$967.6m

Money raised

Freenome is a San Francisco-based company which uses genetic analysis for early cancer detection and risk assessment.

2

Funding Rounds

$18.1m

Money raised

A biotechnology company that develops treatments for cancer and hematologic conditions

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

5

Funding Rounds

$2.5m

Money raised

Ichor Therapeutics is a pre-clinical contract research on aging mechanisms company founded in 2013 by Kelsey Moody.

Key people:

5

Funding Rounds

$26.8m

Money raised

A biotechnology company developing live attenuated vaccines. It was founded in 2012 and is located in New York.

7

Funding Rounds

$249.0m

Money raised

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

Key people:

3

Funding Rounds

$15.0m

Money raised

Biotechnology company developing proteins from algae for animal and human health and address world's food shortages

Key people:

3

Funding Rounds

$52.0m

Money raised

3T Biosciences is a biotechnology company developing immunotherapies.

4

Funding Rounds

$30.0m

Money raised

Company manufacturing 3d printed pharmaceuticals based in San Francisco, CA

Key people:

4

Funding Rounds

$20.5m

Money raised

Zeteo Tech is a company founded by Charles Call.

4

Funding Rounds

$87.8m

Money raised

DNA synthesis company using enzymatic DNA synthesis based in San Francisco.

4

Funding Rounds

Because Animals is a pet food and cellular agriculture technology company founded in 2016 by Shannon Falconer and Joshua Erret, and is located in Philadelphia, Pennsylvania. Because Animals makes 100% animal-free pet foods, treats, and supplements.

7

Funding Rounds

$102.9m

Money raised

Xenex Disinfection Services is a company that provides pulsed xenon ultraviolet-C, room disinfection systems to healthcare facilities

Key people:

1

Funding Rounds

$10.5m

Money raised

SmartPharm Therapeutics is a Cambridge, MA-based gene therapy company applying the next generation of non-viral DNA and RNA technologies to treat serious human diseases.

2

Funding Rounds

$2.0m

Money raised

Antera Therapeutics is an allergy prevention development company.

Key people:

5

Funding Rounds

$425.0m

Money raised

Tmunity Therapeutics is a biotechnology company developing t-cell immunotherapies for the treatment of human diseases.

1

Funding Rounds

$1.2m

Money raised

Bond Pet Foods is a biotechnology company located in Nederland, Colorado, founded in 2015 by Rich Kelleman. Bond Pet Foods is making "cruelty free" real animal protein pet foods using cellular agriculture.

8

Funding Rounds

$851.0m

Money raised

Nature's Fynd is a biotechnology company growing edible proteins founded in 2012.

4

Funding Rounds

$205.5m

Money raised

Biotechnology company developing cell permeable macrocyclic peptide therapeutics using an automated chemistry synthesis.

5

Funding Rounds

$14.5m

Money raised

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

Key people:

1

Funding Rounds

$2.0m

Money raised

Allevi, formerly known as BioBots, is a technology company making 3 dimensional bioprinters and bioinks for their printers. The company was founded in 2014 and located in Philadelphia, Pennsylvania.

Industries:

Key people:

10

Funding Rounds

$274.2m

Money raised

Calysta is a biotechnology company seeking to improve worldwide food security through making animal feed. The company is based out of Menlo Park, California and was founded in 2012 by Josh Silverman.

1

Funding Rounds

$1.0m

Money raised

Sanguine is a company that has the mission to accelerate medical research by eliminating the barriers to patient participation.

4

Funding Rounds

$44.0m

Money raised

C16 Biosciences is a biotechnology company making alternatives to palm oil founded in 2018 by Shara Ticku, David Heller and Harry McNamara.

Key people:

3

Funding Rounds

$117.5m

Money raised

A biopharmaceutical company focused on developing treatments for urea cycle disorders and other rare diseases

Key people:

1

Funding Rounds

$150.0m

Money raised

Nobell Foods is a San Francisco-based alternative protein manufacturer focused on developing and manufacturing plant-based dairy alternatives.

Key people:

3

Funding Rounds

$59.5m

Money raised

64x Bio is a biotechnology company developing a platform for improving speed and scalability of mammalian cell line discovery for pharmaceutical and biotechnology companies.

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