43 Best Blockchain Startups in United States to Watch in 2025

The Definitive Seedtable Ranking of Blockchain Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 341 start-ups with an aggregate funding of $5.2b. The average funding per company in this subset is $121.4m.

Last update to the database: Feb 18, 2025. See changelog.

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1

Funding Rounds

$35.0m

Money raised

Fractal is a gaming marketplace developed to facilitate non-fungible tokens (NFTs).

3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

2

Funding Rounds

$27.0m

Money raised

CryptoKitties is a game built on the Ethereum blockchain in which users can collect and trade virtual kittens.

7

Funding Rounds

$165.1m

Money raised

Figment is a blockchain infrastructure and software provider.

Location:

Key people:

2

Funding Rounds

$29.5m

Money raised

Immunefi is a bug bounty security services platform that focuses on bug bounty and security services for Web3 projects.

Key people:

3

Funding Rounds

$54.2m

Money raised

Layer1 is a cryptocurrency investment and infrastructure platform.

3

Funding Rounds

$764.7m

Money raised

Bitmain is a Beijing-based multinational semiconductor company, founded in 2013, that manufactures products for blockchain and artificial intelligence (AI) applications.

3

Funding Rounds

$2.3m

Money raised

A web and API platform that provides Bitcoin and Altcoin conversion.

1

Funding Rounds

$6.0m

Money raised

Maximum protection and yield, fully protected through Protocol Controlled Underwriting.

6

Funding Rounds

$898.4m

Money raised

Wise, previously TransferWise, is a company that offers money transfers services founded by Kristo Käärmann and Taavet Hinrikus.

1

Funding Rounds

$3.3m

Money raised

ItBit is a platform for institutions and active investors to trade cryptocurrency assets.

9

Funding Rounds

$378.4m

Money raised

Bitso is a cryptocurrency exchange for buying and selling Bitcoin, Ethereum, Litecoin, Bitcoin Cash, TrueUSD, Decentraland, Golem, and Basic Attention Token.

22

Funding Rounds

$1.4b

Money raised

BlockFi is a blockchain platform for high-interest crypto accounts and low-cost credit products.

Key people:

3

Funding Rounds

$10.8m

Money raised

The Ajuna platform provides a simplified way for Unreal and Unity developers to build an incentive layer into their games using tokenized virtual goods.

1

Funding Rounds

$17.2m

Money raised

ArDrive is a blockchain-based storage App.

1

Funding Rounds

$2.1m

Money raised

Cypher is a decentralized synthetic asset protocol.

3

Funding Rounds

$20.0m

Money raised

Upland is a property trading metaverse connected to real-world addresses.

4

Funding Rounds

$23.3m

Money raised

Bitski is a company making a dApp wallet SDK for decentralized applications.

Key people:

2

Funding Rounds

$15.2m

Money raised

Lit Protocol is decentralized access control designed to bring more utility to the web.

6

Funding Rounds

$39.7m

Money raised

Also known as the Daily Muse, The Muse is a company developing an online career platform that provides job listings and career advice to people. It participated in the W12 cohort of Y Combinator. It was founded in 2011 and is located in New York City, New York.

4

Funding Rounds

$8.8m

Money raised

Rentberry is a home rental platform offering decentralized, global, long term rental solution for tenants and landlord.

Key people:

6

Funding Rounds

$9.8m

Money raised

Facial recognition company Kairos today announced the alpha release of the Kairos Protocol, a biometric verification system for cryptocurrency transactions.

9

Funding Rounds

$136.0m

Money raised

Abra offers a cryptocurrency trading application created to streamline online cryptocurrency transfers and investments.

1

Funding Rounds

$4.5m

Money raised

Staked helps investors compound their cryptocurrency investments by participating in staking or lending.

Key people:

6

Funding Rounds

$61.0m

Money raised

Messari is a cryptocurrency data and analytics firm. It's mission is to promote transparency and smarter decision-making in the cryptoasset community. Their open-source data library helps researchers, investors, and regulators make sense of the industry.

10

Funding Rounds

$36.3m

Money raised

Chronicled is a blockchain company founded by Ryan Orr, Samantha Radocchia, Maurizio Greco and David Aho.

1

Funding Rounds

$3.6m

Money raised

A decentralized capital market powered by a cross-margin cross-collateralization clearing engine protocol.

3

Funding Rounds

$60.0m

Money raised

Zora Labs is a marketplace for non-fungible tokens.

3

Funding Rounds

$8.6m

Money raised

Nebula Genomics is a genetics company developing a platform for individuals to get their personal genome sequenced, and then enable them to store and control that information through cryptographic encryption on the blockchain.

Key people:

5

Funding Rounds

$487.0m

Money raised

Anchorage Digital is a global regulated crypto platform that provides institutions with integrated digital asset financial services and infrastructure solutions.

4

Funding Rounds

$12.8m

Money raised

VeriTX Corp. is an East Aurora, New York-based developer of digital supply chain platform, marketplace, and related products and applications offering technologies to secure digital supply chain solutions and data integrity solutions.

3

Funding Rounds

OpenZeppelin provides security products to build, automate, and operate decentralized applications.

3

Funding Rounds

$16.5m

Money raised

Evernym is a software company that develops an open source sovereign identity block chain.

2

Funding Rounds

$3.1m

Money raised

Moon is a crypto payment platform.

Key people:

1

Funding Rounds

NameBase is a cryptocurrency Exchange founded in 2018.

8

Funding Rounds

$217.3m

Money raised

A blockchain and cryptocurrency development company developing blockchain based business solutions for investment funds, administrators, trading firms, exchanges and accounting firms.

Key people:

2

Funding Rounds

$5.9m

Money raised

Mudrex offers a cryptocurrency investment platform

Key people:

3

Funding Rounds

$32.0m

Money raised

Blocknative is a provider of real-time blockchain transaction management and monitoring solutions for public blockchain networks.

Key people:

2

Funding Rounds

$40.0m

Money raised

Valora is built on Celo, a carbon-negative blockchain.

2

Funding Rounds

$21.6m

Money raised

RabbitHole is building a guide through Web3 for contributors to learn how to use and contribute to decentralized apps while earning tokens based on on-chain activity.

1

Funding Rounds

$5.3m

Money raised

Aperture Finance is a cross-chain marketplace for investing strategies in the decentralized finance domain.

Key people:

1

Funding Rounds

$170.0m

Money raised

Autograph is an NFT platform that brings together the iconic brands in sports and culture to create unique digital collections.

1

Funding Rounds

$5.2m

Money raised

Sense Finance is an adding Dimension to DeFi founded in 2021 by Kenton Prescott.

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